đź—¨ About Me

I am currently a research intern at the Representation Learning Lab at the Westlake University working with Prof. Fajie Yuan and collaborating with Dr. Zitong Jerry Wang.

Previously, I received my Master’s degree in Computer Science from Johns Hopkins University and Bachelor’s degree in Computer Science from Wenzhou-Kean University. I did my master thesis advised by Prof. Kimia Ghobadi at Johns Hopkins University on multi-agent simulation. I was fortunate to work with Prof. Aloysius Wong’s Group at Wenzhou-Kean University during my undergraduate where I first stepped into the field of bioinformatics. After graduation, I worked as a lab specialist at Prof. Chongzhi Zang’s Lab at the University of Virginia Medical School exploring epigenomics-related topics.

In addition, I developed a deep learning model for RNA-ligand interaction prediction with Prof. Yanjun Li at University of Florida and later participated in developing a single-cell foundation model in Prof. Xiaojie Qiu’s Lab at Stanford University. I am also working with Prof. Han Xiao’s Group at Rice University Chemistry for developing a robust platform for machine learning guided protein evolution.

I mainly work on the intersection of machine learning and biology in a broad scope. I am interested in foundation models and LLMs for life sciences around the central dogma and how to use them to interpret and discover the biological mechanism.

Research Interests:

  • Genomics and Epigenomics
  • Deep learning for Cancer Biology and Chemical Biology
  • AI for Drug Discovery

đź“– Educations

  • 2022 - 2024, Master of Science in Engineering, Computer Science. Johns Hopkins University. Baltimore, MD
  • 2018 - 2022, Bachelor of Science, Computer Science. Wenzhou-Kean University. Wenzhou, China

đź“° News

đź“ť Publications

ACS Nano
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Integrating Metal–Phenolic Networks-Mediated Separation and Machine Learning-Aided Surface-Enhanced Raman Spectroscopy for Accurate Nanoplastics Quantification and Classification Haoxin Ye, Shiyu Jiang, Yan Yan, Bin Zhao, Edward R Grant, David D Kitts, Rickey Y Yada, Anubhav Pratap-Singh, Alberto Baldelli, Tianxi Yang. ACS Nano, 2024. Featured on Cover

ALIFE 2023
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Simulating Disease Spread During Disaster Scenarios Shiyu Jiang, Heejoong Kim, Fabio Henrique Tanaka, Claus Aranha, Anna Bogdanova, Kimia Ghobadi, Anton Dahbura. The International Conference on Artificial Life, 2023. Code

Bioinformatics
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HNOXPred: a web tool for the prediction of gas-sensing H-NOX proteins from amino acid sequence Shiyu Jiang, Hemn Barzan Abdalla, Chuyun Bi, Yi Zhu, Xuechen Tian, Yixin Yang, Aloysius Wong. Bioinformatics, 2022 Website | Code

IJCNN 2021
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Deblur-yolo: Real-time object detection with efficient blind motion deblurring

Shen Zheng, Yuxiong Wu, Shiyu Jiang, Changjie Lu, Gaurav Gupta. International Joint Conference on Neural Networks, 2021

🧑‍💻 Professional Experience

🔨 Tools

Model

  • Koudou: an agent-based model that simulates the infectious disease spread under college town scenario.

Web server

  • HNOXPred (Prediction of Heme-Nitric oxide/OXygen domains): a web server that predicts gas-sensing H-NOX proteins from amino acid sequences.

Python Package

  • SICER 2.0 (Spatial-clustering Identification of ChIP-Enriched Regions): a ChIP-Seq broad peak calling data analysis method.

🌎 Miscellaneous

Soccer (Visca Barça), Gym, Table tennis, Piano, Travel, etc.